Williamson, Thomas

Sayed Distinguished Professor

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Sayed Distinguished Professor, Chemistry and Biochemistry , College of Science and Engineering

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williamsonr@uncw.edu

910.962.2397

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Selected Publications

Academic Article
- Cannabicitran: Its Unexpected Racemic Nature and Potential Origins. Chirality. 35:540-548. 2023-01-01
- Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach. Magnetic Resonance in Chemistry. 61:22-31. 2023-01-01
- Solution cis-Proline Conformation of IPCs Inhibitor Aureobasidin A Elucidated via NMR-Based Conformational Analysis. Journal of Natural Products. 85:1449-1458. 2022-06-01
- ¹⁹ F‐detected dual‐optimized inverted ¹ J _CC 1,n‐ADEQUATE. Magnetic Resonance in Chemistry. 60:210-220. 2022-02-01
- Calculated and experimental ¹ H and ¹³ C NMR assignments for cannabicitran. Magnetic Resonance in Chemistry. 60:196-202. 2022-02-01
- Development of ¹⁹ F‐detected 1,1‐ADEQUATE for the characterization of polyfluorinated and perfluorinated compounds. Magnetic Resonance in Chemistry. 59:628-640. 2021-06-01
- Structural Revision of a Wnt/β-catenin Modulator and Confirmation of Cannabielsoin Constitution and Configuration.. Chemical Communication. 5658–5661. 2021-05-01
- Development of 19F‐detected 1,1‐ADEQUATE for the characterization of polyfluorinated and perfluorinated compounds.. Magn. Reson. in Chem. 59:628-640. 2021-01-01
- “One-Shot” Measurement of Residual Chemical Shift Anisotropy Using Poly-γ-benzyl-l-glutamate as an Alignment Medium. Organic Letters. 22:8850-8854. 2020-11-01
- Determination of Complex Small‐Molecule Structures Using Molecular Alignment Simulation.. Angew. Chem. Int. Ed.. 59:6172 –6176.. 2020-01-01
- Developing Nonuniform Sampling Strategies to Improve Sensitivity and Resolution in 1, 1‐ADEQUATE Experiments.. Magn. Reson. Chem. 58,:625–640. 2020-01-01
- Interception of the “Bycroft-Gowland” intermediate in the enzymatic macrocyclization of thiopeptides.. Am. Chem. Soc.. 142:13170–13179. 2020-01-01
- Probing in Vitro Release Kinetics of Long-Acting Injectable Nanosuspensions via Flow-NMR Spectroscopy. Mol. Pharmaceutics. 17:530−540. 2020-01-01
- Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A. Editor’s Choice Hot Paper.. Chem. Commun. 56,:7565-7568. 2020-01-01
- Unequivocal Structure Confirmation of a Breitfussin Analog by Anisotropic NMR Measurements.. Chemical Science. 11:12081-12088.. 2020-01-01
- “One-Shot” Measurement of Residual Chemical Shift Anisotropy Using Poly-γ-benzyl-l-glutamate as an Alignment Medium.. Org. Lett.. 22:8850-8854. 2020-01-01
- 13C NMR-Based Approaches for Solving Challenging Stereochemical Problems.. Org. Lett. 21:4072-4076.. 2019-01-01
- Elucidation and Partial NMR Assignment of Mono-Sulfated Maitotoxins from the Caribbean.. Toxicon. 164,:44-50. 2019-01-01
- Enhancing the utility of 1JCH coupling constants in structural studies through optimized DFT analysis.. Chem. Comm. 55:5781-5784. 2019-01-01
- Invited submission Application of Anisotropic NMR Parameters to the Confirmation of Molecular Structure.. Nature Protocols. , 14:217-247. 2019-01-01
- PBLG as a versatile liquid crystalline medium for anisotropic NMR data acquisition.. Chem. Comm. 55:4327-4330. 2019-01-01
- Unexpected Propargylic Retro-Brook Rearrangements in Alkynes. J. Org. Chem. 84:10024−10031.. 2019-01-01
- Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea. Journal of Natural Products. 81:1417-1425. 2018-06-01
- A Mechanistic Investigation of an Iridium-catalyzed Asymmetric Hydrogenation of Pyridinium salts.. Tetrahedron. 74:2182-2190. 2018-01-01
- A Practical Strategy for the Accurate Measurement of Residual Dipolar Couplings in Strongly Aligned Small Molecules. J. Magn. Reson. 291:63-72. 2018-01-01
- Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea.. J. Nat Prod. 81:1417-1425. 2018-01-01
- Enhanced Measurement of Residual Chemical Shift Anisotropy for Small Molecule Structure Elucidation.. Chem. Comm.. 54,:4254-4257.. 2018-01-01
- Incorporating BIRD-based Homonuclear Decoupling in the Dual-Optimized, Inverted 1JCC 1,n-ADEQUATE Experiment.. Magn. Reson. Chem. 56:1029-1036. 2018-01-01
- Trichophycins B-F, chlorovinylidene-containing polyketides isolated from a cyanobacterial bloom.. J. Org. Chem. 83,:13256-13266. T. 2018-01-01
- Unequivocal Determination of Caulamidines A and B: Application and Validation of New Tools in the Structure Elucidation Toolbox.. Chem. Sci. 9,:307-314.. 2018-01-01
- A Rational Pre-catalyst Design for Bis-phosphine Mono-oxide Palladium Catalyzed Reactions.. Chem. Sci. 8:2841-2851. 2017-01-01
- Improving the performance of J-Modulated ADEQUATE Experiments Through Homonuclear Decoupling and Non-Uniform Sampling.. Magn. Reson. Chem. 55:191-197.. 2017-01-01
- In situ Characterization of Pharmaceutical Formulations by Dynamic Nuclear Polarization Enhanced MAS NMR.. J. Phys. Chem. B,. 121:8132-8141.. 2017-01-01
- Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study. J. Am. Chem. Soc. 139,:8337-8345. 2017-01-01
- Small Molecule NMR in the Pharmaceutical Sciences.. Magn. Reson. in Chem. 252. 2017-01-01
- Unequivocal determination of complex molecular structures using anisotropic NMR measurements.. Science. 356. 2017-01-01
- Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei.. Org. Lett.. 18:4786-4789. 2016-01-01
- Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold.. J. Org. Chem.. 81:10631-10640.. 2016-01-01
- Feature Article Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity.. ACS Central Science. 2,:332-340. 2016-01-01
- Homodimericin A: A Complex Hexacyclic Fungal Metabolite.. J. Am. Chem. Soc. 138:12324-12327.. 2016-01-01
- Observation of Potentially Troublesome 2JCC Correlations in 1,1- and 1,1-HD-ADEQUATE Spectra.. Magn. Reson. Chem. 54,:341-345. 2016-01-01
- Selecting the Most Appropriate NMR Experiment to Access Weak and/or Very Long-Range Heteronuclear Correlations.. J. Nat. Prod.. 79:1400-1406. 2016-01-01
- Spotlight Article Determination of Relative Configuration from Residual Chemical Shift Anisotropy.. J. Am. Chem. Soc. 138:9548-9556. 2016-01-01
- Using Electron paramagnetic Resonance (EPR) Spectroscopy to Facilitate Problem Solving in Pharmaceutical Process Research and Development,. J. Org. Chem.. 81:6937–6944. 2016-01-01
- Absolute Configuration of Remisporines A & B.. Org. & Biomolec. Chem. 13:4169-4173. 2015-01-01
- Carbon Multiplicity Editing in Long-Range Heteronuclear Correlation NMR Experiments: A Valuable Tool for the Structure Elucidation of Natural Products. J. Nat. Prod.. , 78,:2236-2241.. 2015-01-01
- Extending Long-Range Heteronuclear NMR Connectivities by HSQMBC-COSY and HSQMBC-TOCSY Experiments.. J. Magn. Reson.. 258,:25-32.. 2015-01-01
- Homodecoupled 1,1- and 1,n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine.. Ang. Chem., Int. Ed.. 54,:10160-10164. 2015-01-01
- Structure elucidation of uniformly 13C labeled small molecule natural products.. Magn. Reson. in Chem. 53:996. 2015-01-01
- Suppression of Phase and Amplitude nJHH Modulations in HSQC Experiments.. Magn. Reson. in Chem.. 53:115-119. 2015-01-01
- Turning Spiroketals Inside Out: A Rearrangement Triggered by an Enol Ether Epoxidation.. Chemistry Open. , 4,:577-580.. 2015-01-01
- Application of 1,n-ADEQUATE and modified variants to structure elucidation and spectral assignment problems.. eMagRes. 3:215-234.. 2014-01-01
- Chromatographic Separation and Assignment of Absolute Configuration of Hydroxywarfarin Isomers.. Chirality,. 26,:95–101. 2014-01-01
- Isolation, Structure Elucidation and Biological Activity of Altersolanol P using Staphylococcus aureus Fitness Test Based Genome-wide Screening.. J. Nat. Prod. 77,:497-502. 2014-01-01
- LR-HSQMBC: A High Sensitivity Technique to Probe Very Long-Range Heteronuclear Coupling Pathways.. J. Org. Chem.. 79,:3887-3984. 2014-01-01
- NMR Structure Elucidation of Small Molecules and Natural Products: Choosing ADEQUATE vs. HMBC.. J. Nat. Prod. 77:1942-1946. 2014-01-01
- Pure In-Phase Heteronuclear Correlation Experiments.. Angew. Chem.,. 53:8379-8382. 2014-01-01
- Simultaneous 1H and 13C Enantiodifferentiation from Highly-Resolved Pure Shift HSQC Spectra.. Chem. Comm. 50,:10214-10217.. 2014-01-01
- The Impact of LR-HSQMBC Very Long-Range Heteronuclear Correlation Data on Computer-Assisted Structure Elucidation.. Org. Biomol. Chem. 12,:9505-9509. 2014-01-01
- Using LR-HSQMBC to Observe Long-Range 1H-15N Correlations.. Tet. Lett. 55:3365-3366.. 2014-01-01
- Using Pure Shift HSQC to Characterize Microgram Samples of Drug Metabolites.. Tet. Lett. 55,:5450-5453. 2014-01-01
- J ‐modulated ¹⁹ F‐ and ¹ H‐detected dual‐optimized inverted ¹ J _CC 1,n‐ADEQUATE: A universal ADEQUATE experiment. Magnetic Resonance in Chemistry.
- Anomalous ¹ H NMR chemical shift behavior of substituted benzoic acid esters. Magnetic Resonance in Chemistry.
- Enhancing the utility of ¹J_CH coupling constants in structural studies through optimized DFT analysis. Chemical Communications. 55:5781-5784.
- Prediction of anisotropic NMR data without knowledge of alignment medium structure by surface decomposition. Physical Chemistry Chemical Physics. 24:20164-20182.
- Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box. Chemical Science. 9:307-314.

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