Intermolecular C(sp³)−H Amination of Complex Molecules Academic Article

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Overview

Abstract

• AbstractA general and operationally convenient method for intermolecular amination of C(sp3)−H bonds is described. This technology allows for efficient functionalization of complex molecules, including numerous pharmaceutical targets. The combination of pivalonitrile as a solvent, Al2O3 as an additive, and phenyl sulfamate as a nitrogen source affords differential reaction performance and substrate scope. Mechanistic data strongly implicate a pathway for catalyst decomposition that initiates with solvent oxidation, thus providing rationale for the marked influence of pivalonitrile on this reaction process.

Authors

• Chiappini, Nicholas D

Publication Date

• 2018-04-01

Published In

• Angewandte Chemie International Edition  Journal

Identity

Digital Object Identifier (doi)

• https://doi.org/10.1002/anie.201713225

Additional document info

Start Page

• 4956

End Page

• 4959

Volume

• 57

Issue

• 18