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Varadarajan, Sridhar
Professor
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E-mail
varadarajans@uncw.edu
Phone
910.962.7350
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Varadarajan, Sridhar
Professor
Positions
Professor
,
Chemistry and Biochemistry
,
College of Science and Engineering
Publications
Research
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Publications
Selected Publications
Academic Article
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Year
Title
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2021-01-01
Mechanistic Investigation of Site-specific DNA Methylating Agents Targeting Breast Cancer Cells.
.
J. Med. Chem.
. 64:12651–12669.
2021-01-01
2021-01-01
Mechanistic investigation of site-specific DNA methylating agents targeting breast cancer cells.
.
Journal of Medicinal Chemistry.
. 64:12651–12669..
2021-01-01
2019-01-01
Reactivity of N3-Methyl-2-Deoxyadenosine in Nucleosome Core Particles.
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Chem. Res. Toxicol.
. 32:2118-2124.
2019-01-01
2017-01-01
Glycoconjugated Site-selective DNA-Methylating Agent Targeting Glucose Transporters on Glioma Cells.
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Biochemistry
. 56:421 – 440.
2017-01-01
2015-01-01
Oral TNFα modulation alters M1/M2 phenotype and neutrophil infiltration, improves cognition and diminishes Tau pathology in the 3xTgAD mouse model
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PLoS ONE
. 10:e0137305/1-e0137305/28.
2015-01-01
2009-01-01
Molecular Dynamics of d(CGCGAATTCGCG)2 Complexed with Netropsin and Its Minor Groove Methylating Analog, Me-lex, Using Explicit and Implicit Water Models
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Journal of Molecular Structure – Theochem
. 894:50-58.
2009-01-01
Presentations
Design and investigation of DNA bis-alkylating agents for increased toxicity towards cancer cells.
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Southeast Regional Meeting of the American Chemical Society
2019-11-01
Targeting breast and prostate cancer cells with DNA-methylating molecules bearing nuclear receptor targeting ligands.
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Southeast Regional Meeting of the American Chemical Society
2019-11-01
The design and synthesis of cyano-nilutamide conjugated DNA bis-methylating molecules that can target androgen receptor positive cancer cells.
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Southeast Regional Meeting of the American Chemical Society
2019-11-01
Testing novel compound EMS2CH2 on tamoxifen resistant estrogen receptor positive (ER+) breast cancer cells and their targeted kill rates.
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UNCW Spring Student Research and Creativity Showcase.
2019-04-01
Glycoconjugated Site-selective DNA-Methylating Agent Targeting Glucose Transporters on Glioma Cells.
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Amer. Chem. Soc. Nat. Mtg
2017-08-01
Design and investigation of a DNA alkylating molecule capable of producing DNA double strand breaks.
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Southeast Regional Meeting of the American Chemical Society
2016-11-01
Cellular uptake study of fluorescently tagged minor groove binders targeting glucose transporters.
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Southeast Regional Meeting of the American Chemical Society
2016-11-01
Cyano-nilutamide conjugated DNA methylating molecules targeting androgen receptor positive cancer cells.
,
Southeast Regional Meeting of the American Chemical Society
2016-11-01
DNA-methylation characteristics of a DNA minor groove alkylator conjugated to various cancer cell-targeting ligands.
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Southeast Regional Meeting of the American Chemical Society
2016-11-01
Testosterone conjugated DNA methylating agents targeted to prostate cancer cells.
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Southeast Regional Meeting of the American Chemical Society
2016-11-01
Cyano-nilutamide conjugates with a DNA minor groove methylating agent for selective destruction of prostate cancer cells.
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Joint Southeastern/Southwest Regional Meeting of the American Chemical Society
2015-11-01
Site-specific DNA methylation targeted to androgen receptor-positive cells.
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Joint Southeastern/Southwest Regional Meeting of the American Chemical Society
2015-11-01
DNA binding, DNA methylation and cell toxicity of estradiol conjugated DNA methylating compounds.
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Amer. Chem. Soc. Nat. Mtg.
2014-08-01
Testing a drug against breast cancer by targeting the estrogen receptor.
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American Society of Virology
2014-06-01
DNA binding, DNA methylation and cell toxicity of estradiol conjugated DNA methylating compounds
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247th National Meeting of the American Chemical Society
2014-03-16
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Department of Chemistry Seminar
2014-02-01
Glucosamine conjugates of a minor-groove methylating agent: DNA-reactivity and cell toxicity
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South Eastern Regional Meeting of the American Chemical Society
2013-11-12
N3-methyladenine on DNA methylation and cell toxicity
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South Eastern Regional Meeting of American Chemical Society
2013-11-12
Site-specific DNA methylation targeted to estrogen receptor-positive cells
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South Eastern Regional Meeting of the American Chemical Society
2013-11-12
Synthesis and screening of small molecules as Tumor Necrosis Factor a inhibitors
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South Eastern Regional Meeting of the American Chemical Society
2013-11-12
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Vidya Prathishtan's School of Biotechnoloty
2013-07-01
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Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital
2013-07-01
Oral Delivery of a Small Molecule Tumor Necrosis Factor α Inhibitor Improves Cognition and Neuroinflammation in the 3xTg Mouse Model of AD
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Society For Neuroscience
2012-10-13
Novel Cytotoxic Agents Targeted to Cancer Cells
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Indian Institute of Technology, Mumbai
2012-06-27
Novel Cytotoxic Agents Targeted to Cancer Cells
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Seminar at Ramnarain Ruia College
2012-06-22
Novel Cytotoxic Agents Targeted to Cancer Cells
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Seminar at Vidyapratishthan School of Biotechnology
2012-06-18
Designing Novel Breast Cancer Drugs
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North Carolina Conference of Graduate Schools
2012-05-23
Design and synthesis of novel DNA-methylating molecules targeted to estrogen receptor-positive breast cancer cells
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7th Annual Research and Creativity Showcase
2012-04-18
Evaluation of newly synthesized DNA methylating compounds for cellular specificity with chemotherapeutic applications
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7th Annual Research and Creativity Showcase
2012-04-18
Effect of process parameters on the nanoporous structure of anodized alumina
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Congresso Anual da ABM
2011-07-01
Modification of nanoporous alumina membranes with poly(acrylic acid) and alkyl amines.
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SouthEast Regional Meeting of the American Chemical Society
2010-12-02
DNA binding studies of site-specific minor groove binders
,
SouthEast Regional Meeting of the American Chemical Society
2010-12-01
DNA methylation and cytotoxic properties of compound designed to produce N3-methyladenine adducts in estrogen receptor-positive cells.
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SouthEast Regional Meeting of the American Chemical Society
2010-12-01
Design of compounds for N3-adenine methylation in cells expressing the GLUT2 glucose transporter
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Southeast Regional Meeting of the American Chemical Society at New Orleans
2010-12-01
Effect of linker modification on the biochemical properties of DNA-methylating molecules targeted to estrogen receptor-positive cells.
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SouthEast Regional Meeting of the American Chemical Society
2010-12-01
Sequence and Groove-Specific DNA Methylation in Targeted Cells
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Seminar at George Mason University
2010-11-18
Cytotoxic, Non-mutagenic DNA damaged targeted to estrogen-receptor positive cells
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Health and Related Studies Student Symposium
2010-04-09
Novel Cytotoxic Agents Targeted to Cancer Cells
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Seminar
2010-04-09
Selective Transport Through Nanoporous Alumina Membranes Surface Modified with Poly(Acrylic acid)
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Health and Related Studies Student Symposium
2010-04-09
Cytotoxic, non-mutagenic DNA damage targeted to estrogen receptor-positive cells
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American Chemical Society National Conference
2010-03-24
Novel Cytotoxic Agents Targeted to Cancer Cells
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Seminar at Applachian State University
2010-01-22
Selective Transport Through Nanoporous Alumina Membranes Surface Modified with Poly(Acrylic acid)
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Staate of North Carolina Undergraduate Research and Creativity Symposium
2009-11-21
Biomimetic Nanostructured Systems Based on The Macromolecular Crowding Principle for Disease Diagnostics
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Micro-Nano Breakthrough Conference
2008-01-01
Chemically Modified Poly(Acrylic Acid) Monolayers in Alumina Nanoporous Membranes for Cancer Detection
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2008 NSTI Nanotechnology Conference and Trade Show,
2008-01-01
Designing compounds capable of forming 3-methyladenine DNA adducts in estrogen receptor positive cells.
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American Chemical Society National Meeting
2008-01-01
Nanoporous Membranes for Biosensors
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2008 World Congress in Powder Metallurgy and Particulate Materials
2008-01-01
Research
Principal Investigator On
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2013-12-01 - 2014-11-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2012-12-01 - 2013-11-01
CSURF Undergraduate Research Supplies Award: DNA binding studies of site-specific minor groove binders
2013-02-01 - 2013-06-01
CSURF Undergraduate Research Supplies Award: DNA binding studies of site-specific minor groove binders
2013-02-01 - 2013-06-01
CSURF Undergraduate Research Supplies Award: DNA binding studies of site-specific minor groove binders
2013-02-01 - 2013-06-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2011-12-01 - 2012-12-01
DNA Binding Studies of Site-Specific Minor Groove Binders
2012-05-01 - 2012-08-01
CSURF Undergraduate Research Supplies Award: DNA binding studies of site-specific minor groove binders
2012-02-01 - 2012-06-01
CSURF Undergraduate Research Supplies Award: DNA binding studies of site-specific minor groove binders
2012-02-01 - 2012-06-01
Cahill Award: Cytotoxic, non-mutagenic DNA damage targeted to cells via glucose transporters
2011-01-01 - 2011-12-01
CSURF Undergraduate Research Supplies Award: DNA binding studies of site-specific minor groove binders
2011-02-01 - 2011-06-01
Synthesis of a Cancer Cell Selective DNA-Methylating Agent
2010-05-01 - 2010-08-01
Selective protein-capture using surface modified nanoporous alumina membranes
2008-12-01 - 2009-12-01
Cytotoxic, Non-mutagenic DNA-methylating Agents Targeting Estrogen Receptor Positive Cells
2008-07-01 - 2009-12-01
Enhancing Undergraduate Research and Creativity Award
Co-principal Investigator On
High sensitivity calorimetry instrumentation to study interactions in biochemical systems
2009-04-01 - 2010-03-01
Investigator On
Acquisition of an NMR console and probe to support research and education
2021-08-01 - 2024-07-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2021-11-01 - 2022-11-01
A1 Biochemical Laboratories Postdoctoral Fellowship
2016-07-01 - 2022-04-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2020-11-01 - 2021-11-01
Synthesis of Key Intermediates for Anti-Breast Cancer DNA Damaging Agent
2021-01-01
Synthesis of Key Intermediates for Anti-Prostate Cancer DNA Damaging Agent
2021-01-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2019-11-01 - 2020-11-01
Novel DNA-damaging chemotherapeutics targeting breast cancer cells.
2019-10-01 - 2020-05-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2018-11-01 - 2019-11-01
A Targeted Chemotherapeutic for Treating ER+ Breast Cancer
2019-01-01
Design and Synthesis of Molecules for Causing Lethal DNA Double Strand Breaks
2019-01-01
Development of Site-Specific DNA Damaging Agents Targeting Cancer Cells
2019-01-01
Novel DNA-Damaging Chemotherapeutics Targeting Breast Cancer Cells
2019-01-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2017-10-01 - 2018-11-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2016-06-01 - 2018-11-01
Analytical Characterization of Novel Chemotherapy Drugs
2018-01-01
Design and Synthesis of Molecules for Causing Lethal DNA Double Strand Breaks
2018-01-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2015-06-01 - 2017-11-01
Small Molecules Targeting G-Quadruplexes for Anti-Cancer Therapy
2017-01-01
Small Molecules Targeting G-Quadruplexes for Anti-Cancer Therapy, research conducted at the Indian Institute of Technology Bombay, India
2017-01-01
Small Molecules Targeting G-Quadruplexes for Anti-Cancer Therapy, research conducted at the Indian Institute of Technology Bombay, India
2017-01-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2014-05-01 - 2015-11-01
Analysis of DNA damage caused by anti-cancer compounds
2015-01-01
Improving uptake of site-specific DNA damaging agents in breast cancer cells using Ladder Frame Polyethers
2014-01-01 - 2015-01-01
Small molecule TNF alpha inhibitors as oral Treatments for Alzheimer’s Disease
2014-01-01 - 2015-01-01
Synthesis of novel compounds for treatment of neuro-inflammatory diseases
2013-12-01 - 2014-11-01
UNCW Summer Undergraduate Research and Creativity Award
2014-01-01
Acquisition of a 600MHz NMR
2009-08-01 - 2012-08-01
Contact
Full Name
Sridhar
Varadarajan